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Condition: secondhand. This Everlast Pacer treadmill is approximately one year old and is available at a negotiable price of R12,500. Perfect for home gyms or fitness enthusiasts looking for reliable exercise equipment at a great value.Enhance your fitness routine with this durable and efficient treadmill. Ideal for walking, jogging, or running, it offers a smooth workout experience with essential features to support your health goals.Brand: EverlastModel: PacerCondition: Secondhand, well-maintainedAge: Approximately 1 yearPrice: R12,500 (negotiable)Type: Treadmill for home useFeatures: Durable frame, smooth motor, adjustable speed settings, safety featuresSuitable for: Walking, jogging, runningLocation: South AfricaWhether you're starting your fitness journey or maintaining an active lifestyle, this Everlast Pacer treadmill provides a reliable and effective workout solution. Contact us today to negotiate the price and make this quality exercise machine yours.
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BAM15 is a research compound centered on a highly advanced metabolic mechanism: mitochondrial uncoupling. Benefits of BAM15 (Mitochondrial Uncoupler)BAM15's unique function is to increase energy expenditure by making the mitochondria—the cell's power plants—less efficient at producing chemical energy (ATP).1. Massive Increase in Energy ExpenditureMitochondrial Uncoupling: This is the core mechanism. BAM15 acts like a "leak" in the inner mitochondrial membrane, allowing protons to pass back into the mitochondrial matrix without going through the ATP synthase enzyme.Fuel Burning: To compensate for the loss of the proton gradient and maintain necessary ATP levels, the mitochondria must burn more fuel (fatty acids and glucose) at an accelerated rate. This results in a significant, continuous increase in Basal Metabolic Rate (BMR) and enhanced calorie burning, similar to processes that occur naturally in brown fat.2. Anti-Obesity and Body Composition EffectsFat Loss: Preclinical studies in mice fed high-fat diets showed that BAM15 treatment decreased body fat mass without requiring a reduction in food intake.Lean Mass Preservation: Crucially, BAM15 demonstrated the ability to reduce fat accrual while preserving lean body mass (muscle tissue), which is a key advantage over early, highly toxic uncouplers.3. Profound Metabolic and Glycemic ControlImproved Insulin Sensitivity: Research strongly suggests BAM15 improves insulin sensitivity across multiple tissue types. In diabetic animal models, it significantly improved glucose tolerance and reduced insulin resistance.Fatty Liver Reduction: It has been shown to decrease hepatic fat (fat in the liver), indicating potential benefits for conditions like non-alcoholic fatty liver disease (NAFLD/NASH).4. Cellular and Oxidative Stress ReductionThe uncoupling mechanism is associated with a reduction in the production of Reactive Oxygen Species (ROS), or free radicals. By mitigating oxidative stress, BAM15 shows potential benefits for overall cellular health, neuroprotection, and a reduction in "inflammation."
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Benefits of Semax PeptideSemax is a heptapeptide (a chain of seven amino acids) that has been studied extensively for its ability to enhance cognitive function and support brain health, particularly after various forms of stress or injury.31. 易 Potent Nootropic and Cognitive EnhancementAttention and Focus: Semax is renowned for its ability to significantly improve attention span, concentration, and focus, particularly under conditions of fatigue or high cognitive load.4 It helps stabilize the nervous system during intense mental work.Memory and Learning: It has been shown to enhance learning capacity and memory consolidation and retrieval, making it a favored compound for complex tasks.5Mental Acuity: Users often report a sense of "mental clarity" and faster processing speed.2. Strong Neuroprotection and RecoveryBDNF and 6$\text{NGF}$ Elevation: Semax has been clinically proven to elevate the levels of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (7$\text{NGF}$) in the hippocampus and cortex.8 These neurotrophins are vital for the survival, growth, and function of neurons.9Post-Stroke and Injury Recovery: Due to its neuroprotective actions, Semax has been studied for aiding recovery from brain injuries, including ischemic stroke, by mitigating damage and facilitating neuronal repair.103. Modulation of Brain ActivityNeurotransmitter Regulation: Semax modulates the activity of several crucial neurotransmitters, including dopamine and serotonin, which are linked to mood, motivation, and reward pathways. This regulation helps boost motivation and contributes to its antidepressant-like effects.Cerebral Circulation: It promotes healthy cerebral blood flow, ensuring that brain tissue receives the necessary oxygen and glucose for optimal performance.114. Adaptive and Anti-Fatigue EffectsSemax acts as a strong adaptogen, helping the body and mind cope with high levels of physical and emotional stress. It is known to reduce the feelings of mental and emotional fatigue associated with chronic stress or intellectual overexertion.
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易 Benefits of Selank PeptideSelank is a heptapeptide (a chain of seven amino acids) that is structurally analogous to the naturally occurring human immunomodulatory peptide tuftsin.4 Its benefits are derived from its complex modulation of neurochemical and immune systems:51. Anxiolytic (Anti-Anxiety) Action Without Sedation6GABA System Modulation: Selank's primary mechanism of action is its interaction with the GABAergic system, specifically the 7$\text{GABA}_{\text{A}}$ receptors.8 $\text{GABA}$ (gamma-aminobutyric acid) is the brain's main inhibitory neurotransmitter, and Selank's action helps to reduce neural excitability.9Non-Sedative Relief: Unlike traditional anti-anxiety drugs (like benzodiazepines), clinical research suggests Selank can reduce elevated anxiety and stress levels without causing sedation, muscle relaxation, or cognitive blunting.10 It is often compared to the effects of low-dose benzodiazepines but without the associated amnesia, withdrawal, or dependence risk.112. Cognitive Enhancement (Nootropic Effects)Improved Clarity: By reducing the mental fog and instability caused by chronic stress and anxiety, Selank can enhance mental clarity and focus.12Memory and Learning: Studies have indicated it can improve short-term and long-term memory formation and retrieval, particularly under stressful conditions.13Neurotransmitter Balance: Selank modulates the concentration of key monoamine neurotransmitters (like dopamine and serotonin), which support mental endurance, attention, and motivational processes.143. Neuroprotection and Stress ResilienceBDNF Elevation: Selank has been shown to rapidly elevate the expression of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus.15 BDNF is vital for supporting existing neurons and encouraging the growth and differentiation of new ones, providing neuroprotective benefits.16Adaptogenic Effects: It helps stabilize the body's response to chronic stress, modulating the HPA (hypothalamic-pituitary-adrenal) axis, thereby increasing stress resilience.174. Immunomodulatory EffectsAs a tuftsin analogue, Selank exhibits immunomodulatory properties, including affecting the balance of 18$\text{T}$ helper cell cytokines.19 This suggests it may play a role in regulating the immune system, which is often suppressed or dysregulated by chronic psychological stress.20Crucial Status Note: Selank is approved for medical use (Generalized Anxiety Disorder and neurasthenia) in Russia and some Eastern European countries.21 However, it is not approved by the U.S. FDA or the European Medicines Agency (EMA) for clinical use. Its availability as a supplement like the "Limitless Performance" nasal spray falls under the "research compound" category, and its use should be approached with caution and preferably with consultation from a specialist familiar with peptides.
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易 Benefits of Methylene Blue (MB)1. ⚡️ Mitochondrial Energy Enhancement (The Core Benefit)This is MB's most critical function. It acts as a rare electron cycler in the mitochondrial electron transport chain (ETC)—the process that creates the cell's energy (ATP):Bypasses Damage: MB can accept electrons from one point in the ETC and donate them directly to another (specifically bypassing Complexes I and III), which is vital if the mitochondria are stressed or damaged.Boosts ATP Production: This electron-shuttling action enhances the overall efficiency of the ETC, leading to increased ATP (cellular energy) production, which is the 'fuel' for high performance, both mental and physical.2. 易 Neuroprotection and Cognitive Enhancement (Nootropic)MB is highly lipophilic (fat-soluble) and crosses the blood-brain barrier easily, allowing it to act directly on neurons:Improved Focus and Memory: By boosting mitochondrial energy in brain cells, MB is associated with enhanced functional connectivity in the brain. Small human studies suggest low doses can improve memory retrieval and sustained attention.Protection Against Degeneration: In preclinical models, MB has shown strong neuroprotective effects by mitigating the oxidative stress and mitochondrial dysfunction common in conditions like stroke and neurodegenerative disorders.3. ️ Potent Antioxidant and Anti-Inflammatory ActionReduces Oxidative Stress: By optimizing electron transfer, MB reduces the 'leakage' of electrons that create damaging Reactive Oxygen Species (ROS), thereby protecting cells from oxidative damage, a major driver of aging.Anti-Inflammatory: It is known to help mitigate neuroinflammation, which is often implicated in brain fog and cognitive decline.4. 喝 Systemic EffectsMB supports oxygen metabolism, and its action as a reversible MAO-A inhibitor at low doses can influence levels of mood-regulating neurotransmitters (like serotonin, dopamine, and norepinephrine), contributing to a potential sense of improved mood and mental clarity.
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The product Limitless Performance – GHK-CU Roll On is a topical application featuring the peptide GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper), one of the most well-researched peptides in dermatology and tissue repair. Benefits of GHK-Cu (Copper Peptide)GHK-Cu is a naturally occurring human plasma copper-binding peptide that declines with age. Its function is primarily to act as a signaling molecule for regeneration and repair.1. ️ Potent Anti-Aging and Skin RegenerationCollagen and Elastin Boost: GHK-Cu is scientifically proven to stimulate the production of key structural proteins—collagen (Types I and III) and elastin. This results in tighter, firmer skin, improved elasticity, and reduced skin sagging.Wrinkle Reduction: By increasing dermal thickness and filling in the structural matrix, it significantly reduces the appearance of fine lines and deep wrinkles.Gene Modulation: Research suggests GHK-Cu can influence the gene expression profile of aged skin cells, "resetting" them to a pattern more similar to that of younger cells, promoting overall vitality.2. 啕 Accelerated Wound Healing and Tissue RepairWound Closure: GHK-Cu is one of the most effective natural compounds for accelerating wound healing, including surgical sites and injuries. It works by attracting immune cells and repair cells to the area.Reduced Scarring: By regulating the breakdown and synthesis of collagen (a process called tissue remodeling), it helps ensure that new tissue forms correctly, leading to less visible scarring.Angiogenesis: It promotes angiogenesis (the formation of new blood vessels) to ensure damaged tissues receive the necessary oxygen and nutrients for optimal repair.3. Anti-Inflammatory and Antioxidant ProtectionSoothes Skin: GHK-Cu acts as a strong anti-inflammatory agent, which is beneficial for calming irritated or inflamed skin conditions and reducing redness.Fights Free Radicals: It possesses powerful antioxidant properties, neutralizing reactive oxygen species (ROS) that contribute to accelerated skin aging from UV damage and pollution.4. 林 Improved Skin Texture and ClarityHyperpigmentation: It can help reduce photodamage and improve the appearance of mottled hyperpigmentation, contributing to a more even and clearer skin tone.Skin Barrier Repair: It helps repair and strengthen the skin's natural protective barrier, leading to better moisture retention and overall skin resilience.
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KPV (Lysine-Proline-Valine) is a tripeptide—a very small fragment—derived from the larger, naturally occurring hormone alpha-melanocyte-stimulating hormone (2$\alpha$-MSH).3 It has been the focus of preclinical research for its potent anti-inflammatory and cytoprotective properties.4️ Benefits of KPV PeptideThe primary and most celebrated benefit of KPV is its remarkable ability to regulate and suppress inflammation.51. Potent Anti-Inflammatory ActionKPV acts as a powerful anti-inflammatory agent, but unlike typical anti-inflammatory drugs, it does so by working inside the cell as a regulator:6NF-7$\kappa$B Inhibition: Its key mechanism is blocking the activation of the NF-8$\kappa$B pathway, which is a "master switch" for inflammation.9 By suppressing this pathway, KPV significantly reduces the production of pro-inflammatory signals, or cytokines (like TNF-10$\alpha$ and IL-6), which fuel chronic inflammation and pain.11Targeted Effect: This focused action is believed to allow it to calm inflammation without completely suppressing the broader immune system, potentially offering a safer profile compared to some traditional anti-inflammatories.122. Gastrointestinal (GI) Tract ProtectionThe oral form of KPV is particularly studied for its benefits within the digestive system:13Gut Barrier Fortification: KPV has been shown in research models to help reinforce the intestinal epithelial barrier integrity.14 This is crucial for preventing "leaky gut" syndrome, where toxins and microbes pass from the gut into the bloodstream and drive systemic inflammation.15Inflammatory Bowel Disease (IBD) Potential: Due to its ability to soothe gut lining inflammation and inhibit key inflammatory pathways in the intestines, it is a promising research subject for conditions like colitis and Crohn's disease.163. Accelerated Tissue and Skin HealingKPV's anti-inflammatory properties directly benefit tissue repair, especially on the skin:17Wound Closure: By rapidly reducing local inflammation at the site of injury, KPV helps support the natural tissue remodeling process, accelerating wound closure.18Dermatitis/Eczema: It is studied for topical applications in inflammatory skin conditions like eczema, psoriasis, and contact dermatitis, where reducing local inflammatory cytokines can minimize redness, swelling, and irritation.194. Potential Antimicrobial PropertiesResearch suggests KPV may also exert mild antimicrobial effects against certain pathogens (like bacteria and fungi), which can further support healing by limiting infection-driven inflammation.20
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✨ Benefits of Nicotinamide Mononucleotide (NMN)Nicotinamide Mononucleotide (NMN) is a naturally occurring molecule that has gained significant attention as a potential anti-aging compound.1 Its key role is being a direct precursor to Nicotinamide Adenine Dinucleotide (2$\text{NAD}^+$), an essential coenzyme found in every cell of the body.3 $\text{NAD}^+$ levels naturally decline with age, and NMN supplementation aims to counteract this decline.4The benefits observed in preclinical (animal) and emerging human studies stem directly from restoring 5$\text{NAD}^+$ levels, which are critical for two primary functions: energy metabolism and cellular repair.61. ⚡️ Enhanced Energy Metabolism and Physical Function7Mitochondrial Support: 8$\text{NAD}^+$ is vital for the reactions in the mitochondria (the cell's "powerhouses") that produce energy (ATP).9 By boosting 10$\text{NAD}^+$, NMN is thought to improve mitochondrial function and overall energy efficiency.11Improved Endurance: Human trials, particularly in middle-aged and older adults, have suggested that NMN supplementation can significantly improve aerobic capacity and physical performance, such as walking endurance and muscle strength.122. 溺 Cellular Repair and "Anti-Aging" EffectsDNA Repair (Sirtuins): 13$\text{NAD}^+$ is a necessary fuel for a group of proteins called sirtuins ("guardians of the genome").14 Sirtuins play a crucial role in maintaining genomic stability by repairing damaged DNA.15 Restoring 16$\text{NAD}^+$ may enhance sirtuin activity, thereby improving cellular resilience.17Telomere Maintenance: Some research suggests NMN may support the health of telomeres (the protective caps on chromosomes), which shorten as cells age.183. Metabolic and Cardiovascular HealthInsulin Sensitivity: Studies, including small-scale human clinical trials, indicate that NMN supplementation can increase muscle insulin sensitivity, a key factor in improving metabolic health, especially in prediabetic or overweight individuals.19Vascular Health: NMN has been linked to promoting vascular health and blood flow by restoring elasticity and reducing age-related oxidative stress in blood vessels.204. 易 Neuroprotection and Cognitive FunctionPreclinical studies suggest NMN may have neuroprotective effects, including supporting neuronal function and improving cognitive capacity by mitigating oxidative stress and promoting better blood flow in the brain.
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Reported Benefits of BPC-157 1. 啕 Accelerated Tissue Healing and RepairThis is perhaps the most celebrated benefit of BPC-157. It is thought to significantly speed up the healing process for various soft tissues:Tendons and Ligaments: Studies have shown it can accelerate the healing of injuries like transected Achilles tendons and damaged ligaments. It may work by promoting the outgrowth, migration, and survival of fibroblasts (cells vital for tissue repair).Muscle Injuries: It has demonstrated effectiveness in healing muscle tears and strains, potentially enhancing the repair of damaged muscle tissue.Bone Healing: Research indicates BPC-157 can accelerate bone fracture healing, possibly by promoting the growth of new bone tissue and enhancing the expression of growth hormone receptors in tendon fibroblasts.2. ️ Gastrointestinal (GI) Tract Protection and HealingGiven its origin from gastric juice, BPC-157 shows remarkable protective effects on the digestive system:Ulcer Treatment: It has shown potent anti-ulcer properties, helping to rapidly heal gastric and intestinal ulcers caused by various factors, including stress, alcohol, and non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen.Gut Lining Repair: It helps maintain the integrity of the mucosal lining, offering potential benefits for conditions like inflammatory bowel disease (IBD) and "leaky gut" syndrome by repairing the intestinal wall.3. Anti-Inflammatory and Pain-Reducing EffectsBPC-157 appears to possess significant anti-inflammatory properties, which contribute to its healing effect:Modulation of Inflammation: It may help to modulate inflammatory pathways, which can reduce swelling and pain associated with injuries, arthritis, and chronic inflammatory conditions.Pain Relief: Some animal studies suggest it may have anti-nociceptive (pain-reducing) effects, which could be beneficial for post-operative or chronic pain.4. 易 Neuroprotective and Central Nervous System (CNS) EffectsEmerging research suggests BPC-157 may protect the brain and nerves:Nerve Repair: It has shown promise in promoting nerve regeneration following injury, potentially aiding in the recovery from conditions like spinal cord compression.Neuroprotection: It may mitigate damage in models of traumatic brain injury and stroke, and it has been suggested to help balance neurotransmitter systems (like dopamine and serotonin), showing potential in managing certain neurological conditions.5. 喝 Angiogenesis (New Blood Vessel Formation)A key mechanism of BPC-157's healing is its ability to promote angiogenesis, the formation of new blood vessels. This is crucial for:Improved Blood Flow: Enhancing blood supply to damaged tissues ensures they receive the necessary oxygen and nutrients for repair.Tissue Regeneration: Better blood flow is fundamental to all forms of regeneration, from soft tissue to bone.
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