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Limitless Performance – Selank – Nootropic Nasal Spray - Next Day Delivery!
R 449
Reason for Reporting
Selank is a heptapeptide (a chain of seven amino acids) that is structurally analogous to the naturally occurring human immunomodulatory peptide tuftsin.4 Its benefits are derived from its complex modulation of neurochemical and immune systems:5
1. Anxiolytic (Anti-Anxiety) Action Without Sedation6GABA System Modulation: Selank's primary mechanism of action is its interaction with the GABAergic system, specifically the 7$\text{GABA}_{\text{A}}$ receptors.8 $\text{GABA}$ (gamma-aminobutyric acid) is the brain's main inhibitory neurotransmitter, and Selank's action helps to reduce neural excitability.9
Non-Sedative Relief: Unlike traditional anti-anxiety drugs (like benzodiazepines), clinical research suggests Selank can reduce elevated anxiety and stress levels without causing sedation, muscle relaxation, or cognitive blunting.10 It is often compared to the effects of low-dose benzodiazepines but without the associated amnesia, withdrawal, or dependence risk.11
Improved Clarity: By reducing the mental fog and instability caused by chronic stress and anxiety, Selank can enhance mental clarity and focus.12
Memory and Learning: Studies have indicated it can improve short-term and long-term memory formation and retrieval, particularly under stressful conditions.13
Neurotransmitter Balance: Selank modulates the concentration of key monoamine neurotransmitters (like dopamine and serotonin), which support mental endurance, attention, and motivational processes.14
BDNF Elevation: Selank has been shown to rapidly elevate the expression of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus.15 BDNF is vital for supporting existing neurons and encouraging the growth and differentiation of new ones, providing neuroprotective benefits.16
Adaptogenic Effects: It helps stabilize the body's response to chronic stress, modulating the HPA (hypothalamic-pituitary-adrenal) axis, thereby increasing stress resilience.17
As a tuftsin analogue, Selank exhibits immunomodulatory properties, including affecting the balance of 18$\text{T}$ helper cell cytokines.19 This suggests it may play a role in regulating the immune system, which is often suppressed or dysregulated by chronic psychological stress.20
Crucial Status Note: Selank is approved for medical use (Generalized Anxiety Disorder and neurasthenia) in Russia and some Eastern European countries.21 However, it is not approved by the U.S. FDA or the European Medicines Agency (EMA) for clinical use. Its availability as a supplement like the "Limitless Performance" nasal spray falls under the "research compound" category, and its use should be approached with caution and preferably with consultation from a specialist familiar with peptides.
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