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Photobiomodulation (PBM) for Alopecia Androgenetic alopecia (AGA) The results of PBM for AGA suggest that the fraction of all the hair follicle (HF) in the anagen phase isincreased. This may be due to the ability of PBM to stimulate the mitochondria in the bulge stem cells. Stem cells are quiescent cells that have adapted to survive in their hypoxic niche. One of the mostdamaging agents to the longevity of cells is oxidative damage to DNA and other biomolecules, caused by the ROS that are an inevitable by-product of aerobic respiration. Therefore stem cells tend to havean overall anaerobic metabolism characterized by low mitochondrial activity and high expression of glycolytic enzymes. Alopecia areata (AA)The mechanism of action of PBM has some differences with that outlined above for AGA. Because AA is an autoimmune disease, the principle molecular signatures are characteristic of a pro-inflammatory nvironment in the HF. PBM has long been known to have a pronounced anti-inflammatory effect, but it is only recently that the possible mechanism for this has become apparent. Cells in the macrophage lineage can assume a diversity of phenotypes, and retain the capability to shift their function to maintain tissue homeostasis. Chemotherapy-induced alopecia (CIA) The mechanism of PBM is likely to operate via a different set of signaling pathways. It has long been known that PBM is able to protect cells at risk of dying. Many in vitro models have been utilized to show that PBM can inhibit apoptosis in different cells triggered by a number of different toxic substances. Thiseffect occurs due to the up-regulation of anti-apoptotic proteins, possible in the mitochondria. Another group of chromophores was identified in the HF, namely opsins. Opsins are blue-light responsivesignaling molecules, that were responsible for reducing apoptosis and prolonging the anagen phase in ex vivo HF that were treated with 3.2 J/cm2 of 453 nm LED light.Items Available: 1
1y
R 250
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New and never used was catridges for salon or personal use.
3d
2
R 500
NEGOTIABLE
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Brand new - Worn onceSize 30Brand - Joyride
7d
VERIFIED
1
R 650
NEGOTIABLE
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Im selling crocs (barely used, looks brand new) and girl/woman jibbits for R650.
12d
1
R 650
NEGOTIABLE
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1 x nailed it box
1 x 500 pcs nail tips
1 x 120ml monomer
1 x pink, white, clear acrylic powder
18 x 10g colour acrylic powders
1 x glass acyclic cup
3 x brush on glue
1 x shiner
1 x buffer
1 x 100 180 nail file
20pcs paper forms
1 x cuticle oil
1 x colour wheel art
1 x diamond wheel art
1 x nail cleaning brush
1 x clip
3 x dotting tools
1x 5pcs acrylic brush set
1 x curved tweezers
1 x 12pcs nail glitter powder
1 x 12pcs nail art accessories
1 x nail edge cutter
13d
1
R 700
NEGOTIABLE
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Men's SIZE 10 Hush Puppy black leather slip-on shoes. Brand new in box with receipt. Cost R1500, selling for R700. Bought wrong size by mistake.
14d
8
R 2,950
NEGOTIABLE
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Manufacturer of Kits for Ladies , Men, Youth Soccer, Netball, Hockey, Basketball, Volleyball, Athletics, Cricket, Rugby, All Sports.Soccer Kits on Sale R 2 950 and R 3300*14 Tops*14 Shorts*Free 1 Goalkeeper Top and Shorts*Free 15 Socks*Free Kit Bag*Free Captains Arm Band*Free WhistleAdditions:Numbers on the shorts R 25 per ShortsLOGO front pocket R 30 per TopShanaaz Albertus@Sports Development Equipment and Kits in Johannesburg, we courier in South Africa (+27) 0738880572 ( Cell / WhatsApp ) (+27) 0832859704 ( Cell / WhatsApp )Facebook:Tradesia Sports
18d
VERIFIED
1
R 400
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New jacket for men in excellent condition
22d
5
R 90
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Womens winter fashion jackets in Stock price R90. All sizes available from S to 4XL
1mo
5
R 600
NEGOTIABLE
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Genuine vintage 1999 t i s s o t l840 k sapphire blue dial women's quartz watch
handmade item
vintage from the 1990s
band material: stainless steel
materials: stainless steel
power: battery
readout: analog
model 1999
caliber : swiss e t a 901 001
s a p p h i r e crystal , blue dial , w r30m
with original stainless steel strap
ref no l840 k
length c l o s e d approx 8cm
watch in working order r u n s
new battery installed
can be personalised
vintage watch w signs of wear
*** p l e a s e n o t e***
vintage jewelry & watches : please be aware that vintage jewelry watches often has some signs of use upon close examination, as well as some patina on sterling items
1mo
5
Negotiable
NEGOTIABLE
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The boots were worn once for A Nike ad to advertise the release of the shoe hence the black duct tape on the cleats to preserve the cleats while walking around on set
2mo
5
R 180
NEGOTIABLE
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Long and three quarter pants in different colours and sizes
2mo
12
Negotiable
NEGOTIABLE
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All used great condition Jordan collection with box and tax also CANVAS ART OF MARVEL VS DC AND MANY MORE ITEMS (ESPECIALLY HAND MADE WOOD "LORD OF THE RINGS"CHESSS SET WITH ALL CHARACTERS FFROM MOVIES, MORE SNEAKERS FOR SALES AND MAMARVEL COLLECTORS NB:more pics available on demand
2mo
8
Negotiable
NEGOTIABLE
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All size 8 sneakers use once for display
2mo
4
R 1,000
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Women’s pants - all size 12.
All stretch fabric
Some new with tags
Some with minor flaws -
Sold as a batch
3mo
6
R 3,500
NEGOTIABLE
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1979 Seiko 5 7009-876A 38mm Automatic Watch, Viking themed modded and meticulously serviced and polished DLW hand and face mod comes with original face and hands and italian leather strap
2mo
VERIFIED
12
Negotiable
NEGOTIABLE
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Speaker galore nikes and addidas more available upon request
4mo
6
Negotiable
NEGOTIABLE
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mutiple watches for sales all new battries Tempo , Tommy Hilfiger ,skone etc
4mo
1
R 122
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Looking for these items must be original and authenticated
7mo
1
R 123
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Hi , looking for these ! Please contact me
1y
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